The association between intracranial pressure and optic nerve sheath diameter on patients with head trauma / Associação entre a pressão intracraniana e o diâmetro da bainha do nervo óptico em pacientes com traumatismo cranioencefálico

Abstract Background: Although intracranial pressure (ICP) monitoring is the gold standard method for measuring intracranial pressure after traumatic brain injury, optic nerve sheath diameter (ONSD) measurement with ultrasound (US) is also used in the evaluation of ICP. Objective: To investigate the association between a series of OSND measurements by US and changes in clinical presentation of the patient. Methods: Prospective study including 162 patients with traumatic brain injury. Age, sex, cerebral CT findings, ONSD levels by US at minutes 0, 60, and 120, Glasgow Coma Scale (GCS) within same period, change of consciousness, treatment, and mortality data were reviewed. The association of ONSD levels with GCS, change of consciousness, treatment, and mortality was evaluated. Results: There was no difference in ONSD changes in the patients' sample within the period (p=0.326). ONSD significantly increased in patients who died (p<0.001), but not in those who survived (p=0.938). There was no significant change in ONSD of the patients who received anti-edema therapy (p=801), but significantly increased ONSD values were found in those who received anti-edema therapy (p=0.03). Patients without change of consciousness did not have any significant change in ONSD (p=0.672), but ONSD values increased in patients who consciousness became worse, and decreased in those who presented a recovery (respectively, p<0.001, p=0.002). A negative correlation was detected between ONSD values and GSC values measured at primary, secondary, and tertiary time periods (for all p<0.001). Conclusions: ONSD follow-up may be useful to monitor ICP increase in patients with acute traumatic brain injury.

RESUMO Antecedentes: Embora o monitoramento da pressão intracraniana (PIC) seja o método padrão-ouro para medir a pressão intracraniana após lesão encefálica traumática, a medição do diâmetro da bainha do nervo óptico (DBNO) com ultrassom (US) também é usada na avaliação da PIC. Objetivo: Investigar a associação entre uma série de medidas de DBNO por US e mudanças na apresentação clínica do paciente. Métodos: Estudo prospectivo incluindo 162 pacientes com traumatismo cranioencefálico. Idade, sexo, achados de TC cerebral, níveis de DBNO por US nos minutos 0, 60 e 120, Escala de Coma de Glasgow (GCS) no mesmo período, mudança de consciência, tratamento e dados de mortalidade foram revisados. A associação dos níveis de DBNO com GCS, mudança de consciência, tratamento e mortalidade foi avaliada. Resultados: Não houve diferença nas mudanças de DBNO na amostra de pacientes no período (p=0,326). O DBNO aumentou significativamente em pacientes que morreram (p<0,001), mas não naqueles que sobreviveram (p=0,938). Não houve mudança significativa no DBNO dos pacientes que receberam terapia antiedema (p=801), mas valores significativamente aumentados de DBNO foram encontrados naqueles que receberam terapia antiedema (p=0,03). Pacientes sem alteração da consciência não tiveram alteração significativa no DBNO (p=0,672), mas os valores do DBNO aumentaram nos pacientes que pioraram a consciência e diminuíram naqueles que apresentaram recuperação (respectivamente, p<0,001, p=0,002). Detectou-se correlação negativa entre os valores de DBNO e os valores de GSC medidos nos períodos primário, secundário e terciário (para todos, p<0,001). Conclusões: O acompanhamento do DBNO pode ser útil para monitorar o aumento da PIC em pacientes com lesão cerebral traumática aguda.

Hematoma subdural crónico / Chronic subdural hematoma

El hematoma subdural crónico (HSC) es una patología neuroquirúrgica frecuente, que se reconoce como consecuencia de traumatismos craneoencefálicos de poca magnitud que habitualmente se diagnostican en pacientes seniles, aunque puede presentarse en pacientes jóvenes y sin antecedentes de traumas.El objetivo que persigue este trabajo es la presentación de una paciente con un HSC bilateral, con características poco usuales.Caso clínico: se presenta una paciente del sexo femenino, de 46 años de edad, sin antecedente de traumatismo craneal ni de otra patología concomitante, que consulta por una cefalea de 15 días de evolución. El examen físico constató midriasis, pupila de Hutchinson, papiledema bilateral y exoforia del ojo derecho, parálisis del tercer par craneal y ataxia de tronco, fue catalogada con Glasgow 13. Se realizó tratamiento anti edema cerebral temprano y las manifestaciones desaparecieron en gran medida. En la Tomografía axial computarizada se diagnosticó un hematoma subdural frontotemporal bilateral con desplazamiento de las estructuras de la línea media a la izquierda. Fue operada de urgencia y dada de alta completamente recuperada tres días después.Conclusión: el HSC puede presentarse con distintas formas clínicas, simulando procesos expansivos tumorales, ataques cerebrovasculares, demencias o entidades neurológicas de otra índole. El manejo del caso por clínicos y neurocirujanos fue rápido y efectivo, lo que explica que la paciente tuvo una recuperación temprana y total. En estos casos la actuación médica es decisiva en el éxito del tratamiento.

Chronic subdural hematoma (CSH) is a common neurosurgical pathology that is recognized as a consequence of minor head injuries that are usually diagnosed in senile patients, although it can occur in young patients without a history of trauma.The objective of this work is the presentation of a patient with a bilateral CSH, with unusual characteristics.Clinical case: a 46-year-old female patient with no history of head trauma or other concomitant pathology is presented, who consulted for a 15-day-old headache. Physical examination confirmed mydriasis, Hutchinson's pupil, bilateral papilledema and exophoria of the right eye, third cranial nerve palsy, and trunk ataxia. She was cataloged with Glasgow 13. Early anti-cerebral edema treatment was performed and the manifestations largely disappeared. A computed tomography scan diagnosed a bilateral fronto temporal subdural hematoma with displacement of the midline structures to the left. She underwent emergency surgery and was discharged completely recovered three days later. Conclusion: HSC can present with different clinical forms, simulating expansive tumor processes, cerebrovascular attacks, dementias or neurological entities of another nature. The case management by clinicians and neurosurgeons was quick and effective, which explains that the patient had an early and complete recovery. In these cases, medical action is decisive in the success of the treatment.

Caracterización de estenosis traqueal por intubación prolongada en pacientes adultos / Characterization of tracheal stenosis by prolonged Intubation in adult patients

La estenosis traqueal es la disminución del calibre de la luz laríngea y traqueal como resultado de la maduración de tejido cicatrizal por lesión isquémica que el balón del tubo endotraqueal produce sobre las mucosas de la pared laringo traqueal cuando es insuflada por encima de la presión capilar (20-30 mm Hg) por un periodo incluso corto. La Asociación Americana de Cuidados Respiratorios recomienda que se utilice intubación para aquellos pacientes que ameriten ventilación mecánica por 7-10 días o menos y traqueostomía para aquellos pacientes que necesitan ventilación por más tiempo. Objetivo: Caracterizar la estenosis traqueal por intubación prolongada. Metodología: Se realizó un estudio descriptivo, retrospectivo que incluyó pacientes adultos con diagnóstico de estenosis traqueal por intubación mayor de 7 días en el Hospital General San Juan de Dios durante enero 2016 a diciembre 2019. Se evaluaron los datos epidemiológicos, clínicos, diagnóstico y terapéuticos en los registros clínicos de los servicios de cirugía torácica, otorrinolaringología y neumología. Resultados: Se evaluaron 52 pacientes adultos con intubación traqueal prolongada que desarrollaron estenosis traqueal. La mayoría son hombres jóvenes con mediana de intubación de dos semanas, la indicación de intubación más frecuente fue por trauma craneoencefálico severo. La forma de diagnóstico más frecuente fue clínico seguido por radiografía y tomografía teniendo en su mayoría estenosis tipo I y II. La mayoría de los pacientes con estenosis traqueal son tratados de manera quirúrgica, comúnmente con traqueostomía, dos semanas después del primer día de intubación. La única variable asociada al tipo de tratamiento fue que se le realizara al paciente una traqueotomía, la cual fue la forma de tratamiento quirúrgico de la mayoría de los pacientes para la corrección de la estrechez traqueal (p=0.01). Conclusiones: el tiempo de intubación endotraqueal es determinante para el desarrollo de la estenosis traqueal. En este estudio se documentaron 52 pacientes que recibieron intubación traqueal prolongada y desarrollaron estenosis traqueal tras una mediana de intubación de dos semanas, lo cual deberá hacernos reflexionar sobre las prácticas y guías para implementar la realización de traqueostomías tempranas en pacientes ventilados después de 7 días (AU)

Tracheal stenosis is the decrease in the caliber of the laryngeal and tracheal lumen as a result of the maturation of scar tissue due to ischemic injury that the balloon of the endotracheal tube produces on the mucosa of the laryngo-tracheal wall when it is insufflated above capillary pressure (20-30 mm Hg) for an even short period. The American Association for Respiratory Care recommends that intubation be used for those patients who require mechanical ventilation for 7-10 days or less and tracheostomy for those patients who require ventilation for longer. Objective: To characterize tracheal stenosis due to prolonged intubation. Methodology: A descriptive, retrospective study was carried out that included adult patients with a diagnosis of tracheal stenosis due to intubation greater than 7 days at the San Juan de Dios General Hospital from january 2016 to december 2019. Epidemiological, clinical, diagnostic and therapeutic data were evaluated in the clinical records of the thoracic surgery, otorhinolaryngology and pulmonology services. Results: 52 adult patients with prolonged tracheal intubation who developed tracheal stenosis were evaluated. Most are young men with a median intubation of two weeks, the most frequent indication for intubation was for severe head trauma. The most frequent form of diagnosis was clinical followed by radiography and tomography, mostly type I and II stenosis. Most patients with tracheal stenosis are treated surgically, commonly with a tracheostomy, two weeks after the first day of intubation. The only variable associated with the type of treatment was that the patient underwent a tracheostomy, which was the form of surgical treatment for most patients to correct the tracheal narrowing (p = 0.01). Conclusions: endotracheal intubation time is decisive for the development of tracheal stenosis. In this study, 52 patients who received prolonged tracheal intubation and developed tracheal stenosis after a median intubation of two weeks were documented, which should make us reflect on the practices and guidelines for implementing early tracheostomies in patients ventilated after 7 days

Intraosseous meningioma mimicking osteosarcoma

Background Predominantly intraosseous meningiomas are rare entities that include true primary intraosseous meningiomas (PIM), as well as meningiomas that may show extensive bone involvement, such as en plaque meningiomas. Different hypotheses have been proposed to decipher the origin of PIMs, such as ectopic arachnoid cap cell entrapment during birth or after trauma. Surgical resection is the treatment of choice of such lesions. Case presentation We present a case of a 65-year-old man with an enlarging mass in the parieto-occipital region that grew slowly and progressively over 13 years, following head trauma during a motor vehicle accident. One year prior to presentation, he started experiencing daily holocranial headaches and blurry vision. CT and MRI studies revealed a permeative midline calvarial lesion measuring 14 cm in greatest dimension with extensive periosteal reaction, extension into the subcutaneous soft tissues, subjacent dural thickening and intracranial extension with invasion of the superior sagittal sinus. The favored pre-operative clinical diagnosis was osteosarcoma. The abnormal calvarium was excised and histopathological examination confirmed the diagnosis of a predominantly intraosseous calvarial meningioma, WHO grade I. Conclusions The present case highlights the importance of histopathologic diagnosis in guiding therapeutic decisions and reiterates the necessity of considering PIM or meningiomas with extensive intraosseous component in the differential diagnosis of calvarial masses, even when imaging suggests a neoplasm with aggressive behavior, such as osteosarcoma.

Análisis de los efectos del consumo de alcohol en la morbi-mortalidad por trauma craneoencefálico / Analysis of the effects of alcohol consumption in traumatic brain injury´s morbidity and mortality

Resumen La intoxicación con alcohol está frecuentemente asociada con trauma craneoencefálico (TCE), pero el impacto del alcohol en la patogénesis y el pronóstico del TCE sigue siendo poco clara. La literatura actual provee evidencia en términos de datos clínicos y experimentales que respaldan los efectos neuroprotectores del alcohol en pacientes con TCE. Para establecer de manera significativa esta relación es necesario el desarrollo de estudios prospectivos observacionales fuertes, con el fin de comprender los efectos del alcohol en los resultados clínicos a largo plazo (incluyendo el resultado neurológico) en pacientes con TCE con una apropiada selección y ajuste del riesgo basal.

Abstract Alcohol intoxication is often associated with traumatic brain injuries (TBIs), but the impact of alcohol on the pathogenesis and prognosis of TBIs remains unclear. Current literature provides evidence in terms of experimental and clinical data supporting alcohol's neuroprotective effects in patients with TBIs. To establish in a significative way this association, there lies a need for strong prospective observational studies, in order to comprehend the effects of alcohol on the long-term outcomes (including the neurological outcome) in patients with TBI with proper selection and baseline risk adjustment.

Events associated with the occurrence of intracranial hypertension in pediatric patients with severe cranioencephalic trauma and monitoring of intracranial pressure / Eventos associados à ocorrência de hipertensão intracraniana em pacientes pediátricos com traumatismo cranioencefálico grave e monitoração da pressão intracraniana

ABSTRACT Objective: To determine the events associated with the occurrence of intracranial hypertension (ICH) in pediatric patients with severe cranioencephalic trauma. Methods: This was a prospective cohort study of patients 18 years old and younger with cranioencephalic trauma, scores below nine on the Glasgow Coma Scale, and intracranial pressure monitoring. They were admitted between September, 2005 and March, 2014 into a Pediatric Intensive Care Unit. ICH was defined as an episode of intracranial pressure above 20 mmHg for more than five minutes that needed treatment. Results: A total of 198 children and adolescents were included in the study, of which 70.2% were males and there was a median age of nine years old. ICH occurred in 135 (68.2%) patients and maximum intracranial pressure was 36.3 mmHg, with a median of 34 mmHg. A total of 133 (97.8%) patients with ICH received sedation and analgesia for treatment of the condition, 108 (79.4%) received neuromuscular blockers, 7 (5.2%) had cerebrospinal fluid drainage, 105 (77.2%) received mannitol, 96 (70.6%) received hyperventilation, 64 (47.1%) received 3% saline solution, 20 (14.7%) received barbiturates, and 43 (31.9%) underwent a decompressive craniectomy. The events associated with the occurrence of ICH were tomographic findings at the time of admission of diffuse or hemispheric swelling (edema plus engorgement). The odds ratio for ICH in patients with Marshall III (diffuse swelling) tomography was 14 (95%CI 2.8-113; p<0.003), and for those with Marshall IV (hemispherical swelling) was 24.9 (95%CI 2.4-676, p<0.018). Mortality was 22.2%. Conclusions: Pediatric patients with severe cranioencephalic trauma and tomographic alterations of Marshall III and IV presented a high chance of developing ICH.

RESUMO Objetivo: Determinar eventos associados à ocorrência de hipertensão intracraniana (HIC) em pacientes pediátricos com traumatismo cranioencefálico grave. Métodos: Trata-se de coorte prospectiva de pacientes de até 18 anos, com traumatismo cranioencefálico, pontuação abaixo de nove na Escala de Coma de Glasgow e monitoração da pressão intracraniana, admitidos entre setembro de 2005 e março de 2014 em unidade de terapia intensiva pediátrica. A HIC foi definida como episódio de pressão intracraniana acima de 20 mmHg por mais de cinco minutos e com necessidade de tratamento. Resultados: Incluídas 198 crianças e adolescentes, 70,2% masculinos, mediana de idade de nove anos. A HIC ocorreu em 135 (68,2%) pacientes; valor máximo de pressão intracraniana de 36,3; mediana 34 mmHg. Receberam sedação e analgesia para tratamento da HIC 133 (97,8%) pacientes, 108 (79,4%) receberam bloqueadores neuromusculares, 7 (5,2%) drenagem de líquor, 105 (77,2%) manitol, 96 (70,6%) hiperventilação, 64 (47,1%) solução salina a 3%, 20 (14,7%) barbitúricos e 43 (31,9%) foram submetidos à craniectomia descompressiva. Os eventos associados à ocorrência de HIC foram os achados tomográficos à admissão de swelling (edema mais ingurgitamento) difuso ou hemisférico. A razão de chance para que pacientes com classificação tomográfica Marshall III (swelling difuso) apresentassem HIC foi 14 (IC95% 2,8-113; p<0,003) e para aqueles com Marshall IV (hemisférico) foi 24,9 (IC95% 2,4-676; p<0,018). A mortalidade foi de 22,2%. Conclusões: Pacientes pediátricos com traumatismo cranioencefálico grave e alterações tomográficas tipo Marshall III e IV apresentaram grande chance de desenvolver HIC.

Prevalência de sequelas neurológicas associadas a trauma em face / Prevalence of neurological sequelae associated with facial trauma

Introdução: pacientes acometidos por traumatismo craniofacial podem evoluir com sequelas variadas. Objetivo: identificar a prevalência de sequelas neurológicas ocorridas entre os pacientes com traumatismo craniofacial em um serviço de referência para o trauma no sul do Brasil. Sujeitos e método: foram analisados 1.385 prontuários, em que 169 (12%) pacientes foram selecionados com trauma em crânio e face simultaneamente, levando em consideração o agente etiológico, a procedência, a idade, o sexo do paciente e a localização das fraturas. Resultados: uma taxa de 85% dos indivíduos era do sexo masculino, com faixa etária entre 31-40 anos. Os fatores etiológicos mais prevalentes foram acidentes de trânsito (36%), quedas (22%) e violência interpessoal (21%). No grupo selecionado, o traumatismo cranioencefálico esteve presente em 89% dos casos; em 64% da população, não houve sequela neurológica; 28% apresentaram algum tipo de sequela; e em 8% dos prontuários não havia informações completas. Conclusão: na população estudada, mesmo com um subgrupo específico de traumatizados, houve prevalência de gênero masculino, terceira década de vida e acidente automobilístico. Além disso, a região anatômica mais acometida foi o conjunto de ossos do terço médio da face, e, ainda nesta condição de associação, o traumatismo cranioencefálico esteve presente na maioria dos casos, porém, somente 28% dos casos evoluíram com alguma sequela neurológica. (AU)

Introduction: patients affected by craniofacial trauma may evolve into various sequelae. Objective: to identify the prevalence of neurological sequelae among patients with craniofacial trauma in a reference trauma service in southern Brazil. Subjects and method: a total of 1.385 medical records were analyzed, from which 169 (12%) patients were selected with simultaneous skull and face trauma, considering the etiologic agent, origin, age and sex of the patient, and fracture location. Results: a rate of 85% of the individuals were men aged 31 through 40 years. The most prevalent etiological factors were car accidents (36%), falls (22%), and interpersonal violence (21%). In this selected group, traumatic brain injury was present in 89% of the cases. In 64% of the population, there were no neurological sequelae, 28% presented some type of sequelae, and 8% of the medical records did not contain complete information. Conclusion: for this population studied, even with a specific subgroup of traumatized subjects, the male sex, the third decade of life, and car accidents are the most prevalent factors. In addition, the most affected anatomic region is the set of bones in the middle third of the face and, in this condition of association, traumatic brain injury was present in the great majority of cases, but only 28% of them evolved into some type of neurological sequelae. (A)

Análise das características de indivíduos com sequelas de traumatismo cranioencefálico (TCE) em um centro de referência em reabilitação (características de TCE) / Analysis of the characteristics of individuals with traumatic brain injury (TBI) in a rehabilitation reference center (TBI characteristics)

INTRODUÇÃO: O Traumatismo Cranioencefálico (TCE)é definido como uma alteração na função encefálica, devido a uma causa externa, ou seja, algum trauma físico de origem externa e que leva à morbimortalidade e incapacidades em todo o mundo. OBJETIVO: Analisar as características (aspectos sociodemográficos, causa do TCE; custos com saúde) de indivíduos com sequelas de traumatismo cranioencefálico em um centro de referência em reabilitação. METODOLOGIA: Estudo de natureza descritiva,retrospectiva e quantitativa no período de janeiro de 2009 a dezembro de 2013, por meio de análise documental, resultando em uma amostra final de 88 prontuários analisados. Foram incluídos indivíduos de ambos os sexos, com idade igual ou superior a dois anos de vida. RESULTADOS: Dos indivíduos com sequelas de TCE, 86,36% eram do sexo masculino, com idade entre 18 e 59 anos (80,68%), apresentando ensino médio completo (26,14%), de cor parda (52,27%) e com renda familiar entre um e cinco salários mínimos (60,23%). A causa mais frequente de TCE foi o acidente motociclístico (68,18%). Não houve diferença estatística entre tipos de causa de TCE e custos com saúde. CONCLUSÃO: O presente estudo demonstrou que grande parte dos indivíduos eram homens jovens e vítimas de acidente motociclístico.(AU)

INTRODUCTION: traumatic brain injury (TBI) is defined as a change in brain function due to an external cause, that is, some external physical trauma that leads to morbidity and mortality, disabilities and mortality worldwide. OBJECTIVE: To analyze the characteristics (Socio-demographic aspects; causes of TBI; Health costs) of individuals with traumatic brain injury sequelae in a referral center for rehabilitation. METHODOLOGY: descriptive, retrospective and quantitative study from January 2009 to December 2013, Through documentary analysis, resulting in a final sample of 88 analyzed medical records. Individuals of both sexes, aged 2 years or more, were included. RESULTS: Of the individuals with TBI sequelae, 86.36% were male, aged between 18 and 59 years (80.68%), with completed secondary education (26.14%), mulatto (52.27 %) and family income between 1 and 5 minimum wages (60.23%). The most frequent cause of TBI were motorcycle accidents (68.18%). There was no statistical difference between types of cause of TBI and health care costs. CONCLUSION: This study showed that most individuals were young men, motorcycle accident victims and who lost work capacity. (AU)

Nervo óptico: medida do diâmetro de sua bainha para detectar hipertensão intracraniana / Optic nerve: measure the diameter of its sheath to detect intracranial hypertension

Resumo Objetivo: este trabalho teve como objetivo realizar uma revisão da literatura sobre a avaliação e detecção da hipertensão intracraniana através da ultrassonografia do nervo óptico. Métodos: revisão narrativa da literatura baseado em um levantamento bibliográfico nas bases de dados eletrônicas: PubMed, LILACS, SCIELO e CINAHL, através do uso dos descritores: Intracranial Hypertension. Optic Nerve. Ultrasonography, seus correspondentes em português e suas intersecções. Foram selecionados 27 artigos publicados no período de 1998-2017. Resultados: os artigos indicaram que a ultrassonografia do diâmetro da bainha do nervo óptico (DBNO) é util na detecção da hipertensão intracraniana. Conclusão: O aumento do DBNO é uma alteração com elevada acurácia para diagnosticar o aumento da pressão intracraniana em pacientes críticos.

Abstract Objective: This work had the objective of reviewing the literature on the evaluation and detection of intracranial hypertension through optical nerve ultrasound. Method: literature review based on a bibliographic survey in the electronic databases: PubMed, LILACS, SCIELO and CINAHL, using the following descriptors: Intracranial Hypertension.Optic Nerve. Ultrasonography, its correspondents in Portuguese and their intersections. We selected 27 articles published in the period of 1998-2017. Results: the articles indicated that ultrasonography of the diameter of the optic nerve sheath (ONSD) is useful in the detection of intracranial hypertension. Conclusion: The increase in ONSD is a highly accurate change to diagnose increased intracranial pressure in critically ill patients.

Post-traumatic Tension Pneumoventricle: Case Report

Pneumoventricle and liquoric fistula are possible complications of traumatic brain injury (TBI), the main cause of morbimortality related to trauma in Brazil. Liquoric fistulae are more common after direct trauma with skull base fractures. However, pneumoventricle is rare and occurs due to excessive cerebrospinal fluid (CSF) drainage in the presence of a poorly compliant ventricle system, resulting in the influx of air to its interior. The pathophysiology of tension pneumoventricle remains uncertain. However, the traumatic cause is certain andmultiple bone fractures of the face and liquoric fistula may contribute to the process. If symptomatic, the tension pneumoventricle can cause rapid clinical deterioration. The authors aim to report a rare case of post-TBI tension pneumoventricle with complete resolution and without signs of recurrence of the liquoric fistula after surgical treatment.

Evolution of optic nerve and retina alterations in a child with indirect traumatic neuropathy as assessed by optical coherence tomography / Evolução das alterações no nervo óptico e na retina em criança com neuropatia traumática indireta avaliadas com tomografia de coerência óptica

ABSTRACT Herein, we describe the case of a 4-year-old child with indirect traumatic optic neuropathy and serial changes of the optic nerve head and retinal nerve fiber layer (RNFL) documented using optical coherence tomography (OCT). Visual acuity improved despite progressive RNFL thinning and optic disc pallor. We concluded that OCT may be useful for monitoring axonal loss but may not predict the final visual outcome.

RESUMO Descrição do caso de uma criança de 4 anos de idade com neuropatia óptica traumática indireta, cujas alterações no nervo óptico e na camada de fibras nervosas da retina foram documentadas com tomografia de coerência óptica seriadas. A acuidade visual apresentou melhora apesar da diminuição progressiva da camada de fibras nervosas e da palidez do disco óptico. Em conclusão, a tomografia de coerência óptica pode ser útil para monitorar a perda axonal na neuropatia óptica traumática indireta, sem no entanto, predizer o desfecho visual.

Effects of Potentilla fulgens on the changes made in the retinal damage induced by traumatic head injury / Efectos de Potentilla fulgens en los cambios producidos debido al daño retinal inducido por lesión traumática en la cabeza

Traumatic head injury is a leading cause of mortality and morbidity. As a result of head trauma occurring in the retina of the various biochemical, histological and immunohistochemical effects were investigated. Sprague­Dawley rats were subjected to traumatic brain injury with a weight-drop device using 300 g-1 m weight­height impact. Twenty one rats were divided into three groups, as group 1 (vehicle-treated control), group 2 (vehicle-treated trauma) group 3 trauma + Potentilla fulgens ( P. Fulgens) 400 mg/kg/day, i.p.). Distilled water was used as vehicle. All rats were decapitated 5 days after the induction of trauma, and the protective effects of P. Fulgens were evaluated by histological, immunohistochemical and biochemical analyses. Although further studies are necessary to evaluate the time-and dose-dependent neuroprotective effects of P. Fulgens. Depending on whether trauma inhibits apoptosis of photoreceptor cells, ganglion cells, it is thought that the the support against the degeneration of neural connections can be considered. This study indicates that P.Fulgens is potentially useful for the treatment of eye disorders induced by traumatic brain injury.

El trauma de cráneo es una de las principales causas de morbilidad y mortalidad. Como resultado de un traumatismo craneal, la retina puede sufrir diversos efectos bioquímicos, histológicos e inmunohistoquímicos. Veintiún ratas Sprague-Dawley fueron sometidas a lesión craneal traumática con un dispositivo, de caída de peso, usando un impacto de 300 g-1 m de peso-altura. Las ratas fueron divididas en tres grupos: grupo 1 (control), grupo 2 (traumatismo) y grupo 3 trauma + Potentilla fulgens (400 mg / kg / día, i. p.). Se usó agua destilada como vehículo en todos los grupos. Las ratas fueron decapitadas 5 días después de la inducción del trauma, y se evaluaron los efectos protectores de P. Fulgens mediante análisis histológicos, inmunohistoquímicos y bioquímicos. Es necesario realizar más estudios para evaluar los efectos neuroprotectores, dependientes del tiempo y la dosis, de P. Fulgens. Dependiendo si el trauma inhibe la apoptosis de las células fotorreceptoras, se estima que la disposición de las células ganglionares ayuda contra la degeneración de las conexiones neuronales. P. Fulgens ha demostrado ser efectivo para el tratamiento de los trastornos oculares inducidos por lesión cerebral traumática.

Epidemiologia do traumatismo cranioencefálico no Brasil / Epidemiology of traumatic brain injury in Brazil

Introdução: O traumatismo cranioencefálico (TCE) é considerado a maior causa de morte e incapacidade em todo mundo, principalmente entre adultos jovens. No Brasil, estima-se que mais de um milhão de pessoas vivam com sequelas neurológicas decorrentes do TCE. Apesar da sua alta prevalência e taxas de incidência em constante elevação, estudos epidemiológicos permanecem escassos. Objetivo: Discutir as evidências disponíveis em relação ao perfil epidemiológico da população brasileira acometida por TCE. Métodos: Realizou- se uma revisão de literatura nas bases de dados SciELO, LILACS e PubMed. Os termos utilizados na busca foram traumatismo cranioencefálico, e/ou epidemiologia, e/ou Brasil. Para a busca no PubMed foram utilizados os termos em inglês traumatic brain injury, e/ou epidemiology, e/ou Brazil. Foram incluídos artigos originais, descritivos e de revisão que não restringiram a causa, a gravidade do TCE e a faixa etária estudada. Resultados: Foram encontrados oito estudos de 1993 a 2015, todos retrospectivos, sendo cinco deles realizados em hospitais de emergência e três baseados em bancos de dados. Indivíduos com menos de 40 anos, do sexo masculino foram os mais acometidos e as causas principais foram quedas e os acidentes de trânsito, destacando-se os motociclísticos. Conclusão: Estudos epidemiológicos robustos sobre o TCE no Brasil ainda são escassos. Todos os estudos foram retrospectivos e apenas dois apresentaram dados nacionais. Nesse contexto, estudos epidemiológicos de caráter prospectivo que investiguem de forma sistemática os fatores associados ao TCE, são urgentemente recomendados. (AU)

Introduction: Traumatic brain injury (TBI) is the leading cause of death and disability worldwide, especially among young adults. In Brazil, it is estimated that more than one million people live with disabilities due to TBI. Despite the high incidence of TBI and related socioeconomic burden, epidemiological studies are scarce. Objective: To discuss the available evidence regarding the epidemiological profile of Brazilian people victims of TBI. Methods: A literature review was conducted on the SciELO, LILACS and PubMed databases. The terms used were traumatic brain injury and/or epidemiology, and/or Brazil. Original, descriptive and review studies that investigated only one specific cause of TBI, only one level of severity or a specific age group were not included in the current review. Results: Eight retrospective articles published between 1993 and 2015 were included. Five studies were conducted in emergency hospitals and three studies were based on databases records. Men under 40 years old were the most affected group, and the main causes of TBI were falls and traffic accidents, especially involving motorcycle. Conclusion: Sound epidemiological studies on TBI are still rare. All studies included were retrospective and only two reported national data. In this scenario, prospective epidemiological studies that systematically investigate the profile of TBI victims in Brazil are urgently necessary. (AU)

Fatores associados às alterações fonoaudiológicas em vítimas de acidentes de motocicletas / Factors associated with speech-language disorders in motorcycle accident victims

RESUMO Objetivo Verificar fatores associados às alterações fonoaudiológicas em vítimas de acidentes motociclísticos. Método Trata-se de um estudo de corte transversal. Foram estudadas vítimas de acidentes motociclísticos assistidas no Hospital da Restauração entre junho e julho de 2014. Os dados foram coletados através da consulta dos prontuários e entrevistas direta com esses acidentados, no momento da internação e após a alta hospitalar. Para análise, foram estudadas as frequências simples, média e teste Quiquadrado de Pearson ou o teste Exato de Fisher. A margem de erro utilizada nas decisões dos testes estatísticos foi de 5% e os intervalos de confiança foram obtidos com confiabilidade de 95%. Resultados Foram estudados 99 indivíduos, sendo 90,9% do gênero masculino, com idade média de 32,7 anos. Constatou-se um alto percentual de condutores alcoolizados (42,3%) e não habilitados (51,5%). Os traumatismos cranianos estavam presentes em 30,3% dos casos. As áreas corporais mais afetadas foram os membros inferiores (71,7%), seguidos da região da cabeça e face (56,6%). Depois da alta hospitalar, 30,3% referiram queixa de alterações fonoaudiológicas e essas mostraram uma associação estatisticamente significativa com não habilitados (p=0,012) e colisões entre motos (p=0,004). Conclusão Verificou-se alto percentual de lesões em região de cabeça e face decorrentes dos acidentes, associadas principalmente à não habilitação para conduzir moto e colisões entre motocicletas, sugerindo que tais fatores podem agravar as lesões fonoaudiológicas.

ABSTRACT Purpose To investigate factors associated with speech-language disorders in victims of motorcycle accidents. Methods This is a cross-sectional study. Victims of motorcycle accidents studied were treated at Hospital da Restauração between June and July 2014. The data were collected by consulting the records and direct interviews with these, at admission and after discharge. For analysis were raised single frequencies, average and chi-square test or Fisher's exact test. The margin of error used in the statistical tests was 5%, and the intervals were obtained with 95% reliability. Results 99 individuals were studied, 90.9% male, the mean age of 32.7 years. It found a high percentage of 42.3% of drunk drivers and 51.5% were not enabled. The Head Injuries were present in 30.3% of cases. The most affected body area were the lower limbs (71.7%), followed by the head and face region (56.6%). It was also found that 30.3% had complaints of speech pathology after hospital discharge and a statistically significant association between speech therapy complaint and not enabled (p=0.012) and collisions between bikes (p=0.004). Conclusion There was a high percentage of lesions in the head and face resulting from accidents, associated mainly not eligible to drive bike and collisions between motorcycles, suggesting that these factors can aggravate injuries speech therapy

Una revisión sistemática del monitoreo de la presión intracraneana en adultos con trauma craneoencefálico severo / A systematic review of intracranial pressure monitoring in adults with severe traumatic brain injury

Objetivos: Revisar sistemáticamente la evidencia relacionada con el monitoreo de la presion intracraneana en unidades de cuidado neurocrítico en el contexto de trauma craneoencefálico severo. Criterios de elección: Ensayos clínicos aleatorizados que comparen el uso del monitoreo de la presión intracraneana (PIC) que muestren un estimado de mortalidad/discapacidad a 6 meses, en pacientes mayores de 12 años de edad con trauma craneoencefálico severo (escala de Glasgow menor a 8). Método de búsqueda: En Medline, el Registro Central de Ensayos Controlados (CENTRAL); PubMed, HINARI, EMBASE; Grupo Cochrane de Lesiones y las listas de referencias de artículos. De acuerdo con el Manual Cochrane para meta-análisis y revisión sistemática. Resultados: No hubo diferencias entre el grupo de PIC y el control en el pronóstico de discapacidad (RR [Riesgo Relativo]1.01, 95 por ciento CI 0.87 to 1.18). Sin embargo, el monitoreo de la PIC reduce la estancia en UCI en comparación con otros métodos. La estancia en UCI con tratamiento cerebral específico también se redujo en comparación con grupo control. Conclusiones: En pacientes con trauma craneoencefálico, no hubo diferencia entre el monitoreo de la PIC y el examen clínico sin embargo, para mantener una PIC baja, hubo una sustancial reducción de requerimiento de solución salina hipertónica y un descenso en la hiperventilación trayendo consigo beneficios para pacientes en UCI.

Objectives: To systematically review the evidence of intracranial pressure monitoring in neuro critical care unit in the context of a severe head injury. Study eligibility criteria: Patients were older than 12 years ,had a severe traumatic brain injury (Glasgow coma scale < 8), that compared the use of ICP monitoring with control, that presented an estimate of mortality/ disability prognosis 6 months after injury.only randomized clinical trials. Methods: Searched MEDLINE, the Central Registerof Controlled Trials (CENTRAL); PubMed, HINARI,EMBASE; Cochrane Injuries group and the reference lists of articles. In accordance with the Cochrane handbook for meta-analysis and systematic review. Results: In the ICP and control groups there was no difference in the prognosis of disability (RR [Relative Risk]1.01, 95 percent CI 0.87 to 1.18). However, ICP monitoring reduced the duration of stay in ICU compared to other surveillance methods. The stay in the ICU with specific medical support for brain injury was also reduced compared to the control group. Conclusions: In patients with severe traumatic brain injury, the ICP monitoring was not difference to imaging and clinical examination. However, by keeping the ICP low there was a substantial reduction in the requirement for hypertonic saline and a decrease in hyperventilation providing benefits to thepatient in the ICU.

Abusive Head Trauma: Epidemiological Aspects and Diagnosis / Trauma Craniano por abuso: aspectos epidemiológicos e diagnostico

Objective Abusive head trauma (AHT) is defined as a severe, non-accidental traumatic brain injury. Early recognition and treatment are instrumental in limiting the immediate complications and long-term disabilities. The goal of this study was to describe our experience with traumatic head injuries in children younger than 2 years of age. Methods We reviewed the medical records of 195 children aged under 2 years with suspected AHTwho presented with a head injury without witnessed accidental trauma, between January 2008 and June 2013. Results AHT was considered in 145 children. Familial problems (ρ » 0.008), cutaneous hematoma/bruising (ρ < 0.001), retinal hemorrhages (ρ < 0.001), and bone fractures (ρ » 0.04), were significantly more frequent in the AHT group. Conclusions The association between the subdural hematoma and retinal hemorrhage, resulting from an unwitnessed and incoherent history of trauma, is a strong argument for AHT, particularly when associated lesions and socioeconomic risk factors are evident.

Objetivo O traumatismo craniano por abuso (AHT) é definido como uma grave lesão cerebral traumática não acidental. O reconhecimento e tratamento precoce são fundamentais para limitar as complicações imediatas e sequelas tardias. O objetivo deste estudo foi descrever a nossa experiência em crianças menores de 2 anos de idade, vítimas de trauma craniano. Métodos Foram revisados os prontuários de 195 crianças com idade inferior a 2 anos com suspeita de AHT, sem trauma acidental testemunhado e com diagnostico de hematoma subdural, entre janeiro de 2008 e junho de 2013. Resultados AHT foi considerado em 145 crianças. Problemas socioeconômicos familiares (ρ » 0,008), hematomas e lesões cutâneas (ρ <0,001), hemorragias retinianas (ρ <0,001), e fraturas em ossos longos (ρ » 0,04), foram significativamente mais frequentes no grupo de crianças com suspeita de AHT. Conclusões A associação entre hematomas subdurais e hemorragia retiniana, resultante de uma história incoerente de trauma sem testemunhas, é um forte argumento para a AHT, particularmente quando lesões cutâneas e fatores de risco socioeconômicos forem identificados.

Trauma craneoencefálico severo: atención prehospitalaria, manejo quirúrgico y monitoreo multomodal / Severe cranioencephalic trauma: prehospital care, surgical management and multimodal monitoring

El trauma craneoencefálico severo representa por lo menos la mitad de las muertes relacionadas con trauma, la patofisiología celular y clínica esta extensamente estudiada y documentada, las opciones de monitorización y tratamiento constituyen los paradigmas actualmente para la el progreso en la sobrevida disminuyendo la probabilidad de secuelas, junto con los principios de manejo general que incluyen entre otros el control de la temperatura, tensión arterial, sedación, ventilación, nutrición hacen posible la calidad en la atención de nuestros pacientes.

Severe brain trauma accounts for at least half of the deaths related to trauma, cellular pathophysiology and clinic it is extensively studied and documented , the monitoring and treatment options are currently paradigms for progress in decreasing the likelihood of survival sequels along with general management principles which include among others the temperature control, blood pressure, sedation, ventilation, nutrition enables quality care for our patients.

Occipital Condyle Fractures in Traumatic Brain Injury­A Review / Fraturas de côndilo occipital no trauma cranioencefálico ­ uma revisão

É bem estabelecido que o diagnóstico da fratura de côndilo occipital tem aumentado nas últimas décadas, provavelmente devido à disponibilidade e ao uso comum da tomografia computadorizada durante a investigação do trauma craniano, além da maior gravidade dos mecanismos de trauma. Por causa da baixa especificidade da apresentação clínica, e também pelo pouco conhecimento sobre o mecanismo de lesão, o diagnóstico desta condição é um desafio para neurocirurgiões. A abordagem terapêutica destes pacientes é baseada em estudos com baixa casuística e em relatos de caso. Uma revisão sobre este tema foi realizada a fim de discutir alguns aspectos controversos sobre o manejo da fratura de côndilo occipital. As fraturas de côndilo occipital são eventos raros, entretanto podem relacionar-se à alta morbidade em pacientes que sofreram trauma encefálico. Alguns sintomas, como intensa dor cervical, podem estar associados com esta fratura; portanto, paciente com suspeita de fratura de côndilo occipital deve ser submetido a investigação radiológica detalhada da região. O diagnóstico precoce desta fratura permite investigação apropriada, minimizando a chance de sequelas.

It is well established that diagnoses of occipital condyle fracture have increased in past decades, probably because of the availability and common use of computed tomography for investigating traumatic brain injuries, as well as themajor seriousness of trauma mechanism. Because of the low specificity of clinical presentation besides the lesion mechanism not well known, this condition is a diagnostic challenge for neurosurgeons. Therapeutic approaches of these patients are based on studies with low samples and case reports. A review of this theme was performed objecting to discuss some controversial topics about management of occipital condyle fracture. The occipital condyle fracture is a rare event, and it, however, could be related to high morbidity in patients who suffered traumatic brain injury. Some symptoms such as severe neck pain are related with this fracture, and thus patients suspicious of this fracture should undergo detailed radiologic investigation of this region. Early diagnosis of this fracture allows appropriate investigation, thus minimizing the risk of sequelae.

Heridas por proyectil de arma de fuego en cráneo: revisión de la literatura / Firearm projectile wounds on skull: literature review

El trauma craneoencefálico es una de las principales causas de muerte en el mundo, y gran parte de estos se asocian a heridas por arma de fuego en cráneo. Conocer el manejo, las características y fisiopatología de la lesión nos permitirá saber abordar estos casos cuando se presenten a los diferentes centros asistenciales, al tiempo que nos permitirá tener en cuenta las posibles complicaciones, para evitar su aparición y así buscar mejorar la morbilidad por esta causa. Siempre acompañado de un manejo integral que permita abarcar todas las dimensiones afectadas.

Traumatic brain injury is a of the leading causes of death in the world, and many of these are associated with gunshot wounds in the skull. To know management the characteristics and pathophysiology of the lesion will tell as deal with these cases when presented to medical centers, while enabling us to take into account of possible complications, to prevent its occurrence and so try to improve morbidity from this cause. Always accompanied by an integrated management that can encompass all affected dimensions.